Recent Publications
ABSTRACTS
■ R.
E. J. Mitchel,
P. Burchart and H. Wyatt. A Lower Dose Threshold for the in vivo
Protective Adaptive Response to Radiation. Tumorigenesis in Chronically
Exposed Normal and Trp53 Heterozygous C57BL/6
Mice. Radiation Research 170:
765-775, 2008
Abstract
■ Bobby
R. Scott, Charles L. Sanders, Ron E. J. Mitchel and Douglas R.
Boreham. CT Scans May Reduce Rather than Increase the Risk of Cancer .
Journal
of American Physicians and Surgeons,
13(1) 8-11, 2008.
Abstract
■ R.
E. J. Mitchel, and 17 other authors,
Scientific Issues and Emerging Challenges for
Radiological Protection, Report of the Expert Group on the Implications of
Radiological Protection Science. OECD Nuclear Energy Agency report No. 6167,
OECD Publishing, Paris, 2007 [ISBN 978-92-64-99032-6].
Abstract
■ R. E.
J. Mitchel. Low Doses of Radiation Reduce Risk
in vivo. Dose-Response,
5(1) 1-10, 2007.
Abstract
■ H.
Schöllnberger, R. E. J. Mitchel, J. L. Redpath, D. J. Crawford-Brown
and W. Hofmann. Detrimental and Protective Bystander Effects: A Model
Approach. Radiation Research 168: 614-626, 2007
Abstract
■ R.
E. J. Mitchel.
Cancer and Low Dose
Responses in vivo: Implications
for Radiation Protection.
Dose-Response
5: 284–291, 2007.
Abstract
■ R.
E. J. Mitchel, P. Burchart and H. Wyatt.
Fractionated, Low-Dose-Rate Ionizing Radiation Exposure and Chronic
Ulcerative Dermatitis in Normal and
Trp53
Heterozygous C57BL/6 Mice. Radiation Research
168, 716-724 (2007).
Abstract
■ R.
E. J. Mitchel, A. Trivedi, H. Wyatt, M. Hasu, V.
Barrette and
S. C. Whitman. Atherosclerotic
Lesion Development in Gamma Radiation Exposed Apolipoprotein E-/- Mice, Submitted
for publication 2007 Abstract
■ H.
Schöllnberger, R. E. J. Mitchel, Douglas J.
Crawford-Brown, W. Hofmann.
Detrimental bystander effects within a model for chromosome aberrations and
neoplastic transformation. Submitted for publication 2007
Abstract
■ H.
Schöllnberger, R. D. Stewart, and R. E. J. Mitchel. A model
for low dose effects of low-LET
radiation delivered
at high dose rates, International Journal of Low Radiation, 3(2/3)
135-142, 2006 Abstract
■ R.
E. J. Mitchel,
Adaptive Response in vitro and in vivo and its Impact on Low-Dose Radiation
Risk, in Chapter 10. Biological Effects of Low doses of Ionizing
Radiation, in Advances in Medical Physics 2006, (A. B. Wolbarst, R.
G. Zamenhof, W. R. Hendee, eds.) Medical Physics Publishing, Madison, WI,
USA, 2006.
Abstract
■
R. E.
J. Mitchel,
Cancer and Low Dose Responses in vivo: Implications for
Radiation Protection. Canadian Nuclear Society Bulletin,
27(4) 23-26, 2006.
Abstract
■
J. L. Redpath and R. E. J. Mitchel. Enhanced biological
effectiveness of low energy X-rays and implications for the UK
breast screening programme. Br. J. Radiol.
Correspondence. 79: 854-855, 2006.
Abstract
■ H.
Schöllnberger,
R.
E.
J.
Mitchel,
D.J. Crawford-Brown, W. Hofmann
. A model for the induction of chromosome aberrations through direct and
bystander mechanisms, Radiation Protection Dosimetry..
122
(1-4) 2006
Abstract
■ D. R. Boreham, J.-A. Dolling, C. Somers, J. Quinn
and R. E. J. Mitchel.
The adaptive response and protection against heritable mutations and fetal
malformation. Dose-Response,
4(4):317–326,
2006.
Abstract
■ R.
E. J. Mitchel.
Low doses
of radiation are protective in vitro and in vivo: Evolutionary
origins. Dose Response
4(2): 75-90, 2006
Abstract
■ R.
E. J. Mitchel. Radiation risk prediction and genetics: the influence of
the Tp53 gene in vivo, Dose-Response, 3(4) 519-532, 2005.
Abstract
■ H. Schöllnberger, R. D.
Stewart, and R. E. J. Mitchel. Low-LET-induced radioprotective
mechanisms within a stochastic two-stage cancer model,
Dose-Response, 3(4) 508-518, 2005
Abstract
■ R. E. J. Mitchel. The Bystander Effect: Recent Developments and Implications for
Understanding the Dose-Response. Nonlinearity in Biology, Toxicology and
Medicine, 2(3) 173-183, 2004
Abstract
■ D.
R. Boreham, J-A Dolling, C. Somers, J. Quinn and R. E. J. Mitchel,
The Adaptive Response and Protection against Heritable Mutations and
Fetal Malformation, Pacific Basin Nuclear Conference, 2004.
www.pacificnuclear.org - see Publications, Adaptive Response Technical
Sessions
■ R.
E. J. Mitchel, Low Doses of Radiation Reduce
Risk in vivo, Pacific Basin Nuclear Conference, 2004.
www.pacificnuclear.org - see Publications, Adaptive Response
Technical Sessions
■ R.
E. J. Mitchel, J. S. Jackson and S. M.
Carlisle. Upper Dose Thresholds for Radiation-Induced Adaptive Response
Against Cancer in High-Dose-Exposed, Cancer-Prone, Radiation-Sensitive
Trp53 Heterozygous Mice. Radiation Research, 162(1):
20-30 2004.
Abstract
■ H.
Schöllnberger, R.D. Stewart, R. E. J. Mitchel, and W. Hofmann. An
examination of radiation hormesis mechanisms using a multi-stage
carcinogenesis model. Nonlinearity in Biology, Toxicology and
Medicine, 2(4) 317-352 (2004).
Abstract
■ R.
E. J. Mitchel and S. Sunder, Depleted Uranium
Dust From Fired Munitions: Physical, Chemical And Biological Properties,
Health Physics, 87(1): 57-67, 2004.
Abstract
■ B.
A. Ulsh, S.
M.
Miller, F. F. Mallory,
R. E. J. Mitchel, D.
P. Morrison
and D.
R. Boreham. Cytogenetic
dose-response
and adaptive response in
cells of
ungulate
species
exposed to
ionizing
radiation, Journal of
Environmental Radioactivity, 74:
73-81 2004.
Abstract
■ R.
E. J. Mitchel,
and R. A. McCann, Skin Tumor Promotion By
Vitamin E In Mice: Amplification By Ionizing Radiation And Vitamin C,
Cancer Detection and Prevention, 27:102-108, 2003.
Abstract
■ R.
E. J. Mitchel, J.
S. Jackson, D. P. Morrison and S. M. Carlisle, Low Doses of Radiation
Increase the Latency of Spontaneous Lymphomas and Spinal Osteosarcomas in
Cancer Prone, Radiation Sensitive Trp53 Heterozygous Mice,
Radiation Research,
159:320-327
2003.
Abstract
■
H. Schöllnberger, R. E. J. Mitchel, E. I.
Azzam,
D. J. Crawford-Brown, and W. Hofmann,
Explanation of Protective Effects of Low Doses of
g-Radiation
With A Mechanistic Radiobiological Model,
International Journal of Radiation Biology,
78:1159-1173 2002.
Abstract
■
H.
Schollnberger,
R. E.
J.
Mitchel,
D. J. Crawford-Brown and W. Hofmann. Nonlinear dose–response relationships
and inducible cellular defence mechanisms. Journal of Radiological
Protection
22:A21–A25
2002.
Abstract
■ D. R. Boreham, J-A. Dolling, J.
Misonoh, and R. E. J. Mitchel, Teratogenic Effects of Mild Heat Stress
During Mouse Embryogenesis: Effect of Trp53. Radiation Research
158:443-448 2002.
Abstract
■
D. R. Boreham, J-A. Dolling, J. Misonoh, and R. E. J. Mitchel,
Radiation Induced Teratogenic Effects in Fetal Mice with Varying Trp53
Function: Influence of Prior Heat Stress, Radiation Research 158:449-457 2002. Abstract
■
R. E. J. Mitchel,
J-A. Dolling, Jun Misonoh, and Douglas R. Boreham, Influence of Prior
Exposure to Low Dose Adapting Radiation on Radiation Induced Teratogenic
Effects in Fetal Mice With Varying Trp53 Function. Radiation
Research 158:458-463 2002.
Abstract
■
E. J. Broome, D. L. Brown and R. E. J. Mitchel, Dose Responses
for Adaption to Low Doses of 60Co-γ
and 3H-β Radiation in
Normal Human Fibroblasts, Radiation Research, 158:181-186,
2002. Abstract
■
R. E. J. Mitchel,
Low-Dose Radiation Risk: A Biological Reality Check, In Radwaste
Solutions (published by the American Nuclear Society) 9:30-35, 2002. Abstract
■
R. E. J. Mitchel, Radiation Biology of Low Doses, ATW. International Zeitschrift fur
Kernenergie, 47(1):28-30, 2002.
Abstract
■
Trevor Dewit, Victor Clulow, J. S. Jackson and R. E. J. Mitchel,
Uranium And Uranium Decay Series Radionuclide Dynamics In Bone Of Rats
Following Chronic Uranium Ore Dust Inhalation, Health Physics, 81:502-513, 2001. Abstract
■
R. E. J. Mitchel
and D. R Boreham,
Radiation
Protection In The World Of Modern Radiobiology: Time For A New Approach,
Proceedings of 10th International Congress of the International Radiation
Protection Association,
Plenary
Session 1-2 p. 140,
Hiroshima, Japan,
2000.
Abstract
■ D. R. Boreham, J-A. Dolling, S.R. Maves, N. Siwarungson and R. E. J.
Mitchel, Dose rate effects for apoptosis and micronucleus formation in
gamma-irradiated human lymphocytes, Radiation Research. 153:579-586,
2000. Abstract
■
J-A. Dolling, D.R. Boreham, M.E. Bahen and R. E. J. Mitchel,
Role of rad9-dependent cell cycle checkpoints in the adaptive
response to ionizing radiation in yeast, Saccharomyces cerevisiae,
International Journal of Radiation
Biology.
76:1273-1280, 2000.
Abstract
■
Cregan, S. P., Brown, D. L. and Mitchel, R. E. J.
Apoptosis and the Adaptive Response in Human Lymphocytes.
International Journal of Radiation
Biology.
75:1087-1094, 1999.
Abstract
■
Cregan, S. P., Smith, B. P., Brown, D. L and Mitchel, R. E.
J. Two Pathways for the Induction of Apoptosis in Human Lymphocytes.
International Journal of Radiation Biology.
75:1069-1086, 1999.
Abstract
■
Mitchel, R. E. J.,
Jackson, J. S., McCann, R. A. and Boreham, D. R. Adaptive response
modification of latency for radiation-induced myeloid leukemia in CBA/H
mice. Radiation Research. 152:273-279, 1999.
Abstract
■
Dolling, J.-A., Boreham, D. R., Brown, D. L., Raaphorst, G. P. and
Mitchel, R.
E.
J. Cisplatin-modification of DNA repair and ionizing
radiation lethality in yeast, Saccharomyces cerevisiae. Mutation
Research. 433:127-136, 1999.
Abstract
■
Broome, E. J., Brown, D. L. and Mitchel, R. E. J. Adaption of
human fibroblasts to radiation alters biases in DNA repair at the chromosome
level. International Journal of
Radiation Biology.
75:681-690, 1999.
Abstract
■
Broome, E.J., Brown, D. L. and Mitchel, R. E. J. Fluorescence in
situ hybridization of micronuclei in binucleate fibroblasts: A protocol for
cytoplasmic preservation. Biotechniques. 26:610-612,
1999.
Abstract
■
Graham, J. Higson, ,
D. J., Jun, J-S., Kobayashi, S. and Mitchel,
R. E. J. Low doses of
ionising radiation incurred at low dose rates. Journal of the
Australasian Radiation Protection Society, 16:32-47, 1999.
Abstract
■
Mitchel, R. E. J.,
Heinmiller, B. and Jackson, J. S., Inhaled Uranium Ore Dust and Lung Cancer
Risk in Rats. Health Physics. 76:145-155, 1999.
Abstract
■
J. Graham, D. J. Higson, J-S. Jun, S. Kobayashi and R. E. J. Mitchel.
Low doses of ionising radiation incurred at low dose rates. Chapter
7 In Worldwide Integrated View On Main Nuclear Energy Issues,
Published by the European Nuclear Society, Belpstrasse, 23 (P.O. Box 5032),
CH-3001 Berne Switzerland) 1999.
Abstract
■
Dolling, J-A., Boreham, D.
R., Brown, D.
L.,
Mitchel, R.
E.
J. and
Raaphorst, G.P., Modulation of Radiation-Induced Strand Break Repair by
Cisplatin in Mammalian Cells. International Journal of Radiation Biology.
74:61-69, 1998.
Abstract
■
Boreham, D.
R., Dolling, J.-A., Maves, S.
R., Miller, S., Morrison, D.
P.
and Mitchel, R.
E.
J., Heat-Induced Thermal Tolerance and Radiation
Resistance to Apoptosis in Human Lymphocytes. Biochemistry Cell Biology.
75:393-397,1997.
Abstract
■
Dolling, J-A., Boreham, D.
R., Brown, D.
L., Raaphorst, G.
P. and
Mitchel, R.
E.
J., Rearrangement of Human Cell Homologous Chromosome
Domains in Response to Ionizing Radiation. International Journal of
Radiation Biology. 72:303-311, 1997.
Abstract
■
Mitchel, R. E. J.,
Azzam, E. I. and de Toledo, S. M., Adaption to Ionizing Radiation in
Mammalian Cells, In Stress-Inducible Processes in Higher
Eukaryotes, T. Koval (editor), Plenum Press, New York, 1997 pp. 221-243,
1997.
Abstract
■ Azzam, E. I., de Toledo, S. M., Raaphorst, G. P. and Mitchel, R. E. J., Low-Dose Ionizing
Radiation Decreases the Frequency of Neoplastic Tranformation to a Level
Below the Spontaneous Rate in C3h 10t 1/2 Cells, Radiation Research,
146:369-373, 1996.
Abstract
